Innovative Approaches to Analysing Moisture Interactions in Pharmaceutical Materials with Dynamic Vapor Sorption (DVS) – Microbioz India

Innovative Approaches to Analysing Moisture Interactions in Pharmaceutical Materials with Dynamic Vapor Sorption (DVS) – Microbioz India

In the pharmaceutical industry, maintaining the stability and efficacy of drug formulations is a critical challenge. Issues such as batch-to-batch variation, amorphous content, and hygroscopicity can significantly impact the quality and performance of pharmaceutical products. Dynamic Vapour Sorption (DVS) technology has demonstrated its use as a vital tool for scientists in the pharmaceutical field, offering precise measurements and valuable insights into moisture interactions. The DVS method for measuring moisture sorption on pharmaceutical materials involves placing a prepared sample in a microbalance chamber where the relative humidity (RH) is precisely controlled. The process begins with stabilizing the sample at a low RH to establish a baseline mass. Subsequently, the RH is incrementally increased, and the sample is allowed to equilibrate at each step until a stable mass is recorded. This continues until the maximum target humidity is reached, followed by a desorption phase where the RH is gradually decreased. Throughout this process, the DVS records the mass changes, enabling the generation of sorption and desorption isotherms that plot the equilibrium moisture content against RH (Figure 1). These isotherms are crucial for analysing hygroscopicity, detecting hydrate formation, quantifying amorphous content, and identifying moisture-induced phase transitions. [caption id=

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